If the NSA cannot completely secure their network, then what hope does your average network administrator have with a fraction of the budget and manpower? Are those firewall rules, password policies, and security updates just pissing into the wind?
Hopefully not, but it is interesting to consider a security design around the premise that your systems are compromised, that each user is or could be malicious, and that your network is as open as the wi-fi at Starbucks.

